In a desperate attempt to reach his ill wife, organist Anton Phibes (Vincent Price) is horrifically disfigured in a car accident and presumed dead. When he learns that his wife died during an operation, Phibes blames her surgeons and plots an elaborate revenge to punish them for their incompetence. With the help of a mute assistant (Virginia North), Phibes creates a mask resembling his own face and murders the surgeons one by one using bizarre methods inspired by the biblical plagues.